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Ambulatory systems allow the animals
unrestrained and untethered freedom of movement at all times. Some
European countries have instituted regulatory guidelines which
virtually ban tethered infusion in large animals due to the belief that
untethered systems put less stress on the animal subjects. New
advancements in pump technology, jacket design, catheter material, and
surgical techniques and the happier appearance of the animals have made
this the system of choice for many researchers.
The basic ambulatory infusion system includes: infusion pump, jacket,
extension line and internal catheter. The ambulatory pump is placed
inside a fitted pocket that is attached to the animals jacket. An
extension line runs through a hole in the back of the pocket from the
pump to the catheter. The connection between the pump and catheter
depends on which catheter system you chose. There are two internal
catheter systems to choose from. The first system (Figure 1) is the
exteriorized catheter that luer locks to the extension line. The second
system (Figure 2) is the vascular access port that uses a Huber needle
and extension line. The vascular access port allows for easy access and
less chance of infection but involves anchoring the Huber needle to the
insertion site.
Having decided on which style of catheter system to use, the biggest
decision becomes choosing the appropriate pump. There are a number of
high quality pumps to choose from. Many of them provide a wide range of
delivery options. Choose a pump that is capable of delivering the
appropriate volumes and rates you require, small enough to be carried
and has a history of standing up to the rigors of on-animal
applications. Keep in mind, the volume of solution to be delivered
over the infusion period will often weigh more than the pump itself and
must also be carried by the animal.
Below we have assembled the system we recommend using for any
continuous infusion study in the primate. We have chosen this
representative system based on our personal experience and the
successful experiences of our clients.
For more information on selecting the right catheter and pump for your
research see the General Principles section at the beginning of this
publication or give us a call and we will be happy to assist in putting
together the right system for you. | 